| 102 | M Azharuddin | India v South Africa at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 97 | SR Tendulkar | India v South Africa at Mumbai, 1st Test, 24/02/2000 [1484] |
| 97 | L Klusener | South Africa v India at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 95 | JH Kallis | South Africa v India at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 85 | N Boje | South Africa v India at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 79 | G Kirsten | South Africa v India at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 53 | DJ Cullinan | South Africa v India at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 50 | G Kirsten | South Africa v India at Mumbai, 1st Test, 24/02/2000 [1484] |
| 47 | HH Gibbs | South Africa v India at Mumbai, 1st Test, 24/02/2000 [1484] |
| 46 | HH Gibbs | South Africa v India at Mumbai, 1st Test, 24/02/2000 [1484] |
| 41* | AB Agarkar | India v South Africa at Mumbai, 1st Test, 24/02/2000 [1484] |
| 37 | R Dravid | India v South Africa at Mumbai, 1st Test, 24/02/2000 [1484] |
| 36* | JH Kallis | South Africa v India at Mumbai, 1st Test, 24/02/2000 [1484] |
| 36* | A Kumble | India v South Africa at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 33 | L Klusener | South Africa v India at Mumbai, 1st Test, 24/02/2000 [1484] |
| 31 | SC Ganguly | India v South Africa at Mumbai, 1st Test, 24/02/2000 [1484] |
| 28 | A Kumble | India v South Africa at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 27* | MV Boucher | South Africa v India at Mumbai, 1st Test, 24/02/2000 [1484] |
| 23 | W Jaffer | India v South Africa at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 23 | M Kaif | India v South Africa at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 22 | R Dravid | India v South Africa at Mumbai, 1st Test, 24/02/2000 [1484] |
| 21 | SR Tendulkar | India v South Africa at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 20 | G Kirsten | South Africa v India at Mumbai, 1st Test, 24/02/2000 [1484] |
| 20 | SR Tendulkar | India v South Africa at Bangalore, 2nd Test, 02/03/2000 [1486] |
| 20 | NR Mongia | India v South Africa at Bangalore, 2nd Test, 02/03/2000 [1486] |